PUBLICATIONS
2024
Wilson EN, Wang C, Swarovski MS, Zera KA, Ennerfelt HE, Wang Q, Chaney A, Gauba E, Ramos Benitez JA, Le Guen Y, Minhas PS, Panchal M, Tan YJ, Blacher E, Iweka CA, Cropper H, Jain P, Liu Q, Mehta SS, Zuckerman AJ, Xin M, Umans J, Huang J, Durairaj AS, Serrano GE, Beach TG, Greicius MD, James ML, Buckwalter MS, McReynolds MR, Rabinowitz JD and Andreasson KI. (2024). TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer disease mouse models Nature Neuroscience https://doi.org:10.1038/s41593-024-01610-w (2024).
2023
Kara N, Agbaegbu Iweka C and Blacher E. (2023). Chrono‐Gerontology: Integrating Circadian Rhythms and Aging in Stroke Research Advanced Biology 7 (11), 2300048 (2023).
Agbaegbu Iweka C, Seigneur E, Latif Hernandez A, Herrera Paredes S, Cabrera M, Blacher E, Tsai Pasternak C, Longo FM, de Lecea F and Andreasson KI (2023). Myeloid deficiency of the intrinsic clock protein BMAL1 accelerates cognitive aging by disrupting microglial synaptic pruning Journal of Neuroinflammation. 20, 48 (2023).
2022
Lautman Z*, Winetraub Y*, Blacher E*, Terem I, Yu C, Chibukhchyan A, Marshel JH and de la Zerda A. (2022). Intravital 3D visualization and segmentation of murine neural networks at micron resolution Scientific Reports Scientific Reports. 12, 13130 (2022).
2021
Blacher E*, Tsai C*, Litichevskiy L*, Shipony Z, Agbaegbu Iweka C, Markus Scneider K, Chuluun B, Heller CH, Menon V, Thaiss CA and Andreasson KI. (2021). Aging disrupts homeostatic circadian gene regulation and function in macrophages. Nature Immunology. 23 (2): 229-236. Featured in Nature immunology News & Views, Curtis and Carroll, Aging alters rhythms in immunity. doi.org/10.1038/s41590-021-01099-6 and in McRae HM, Hargreaves DC. Old macrophages lose their (circadian) rhythm. Trends Immunol. 2022 Apr;43(4):265-267. doi: 10.1016/j.it.2022.02.005. Epub 2022 Mar 10.
Blacher E. (2021). Can microbes combat neurodegeneration? Identifying a missing link between microbiome and metabolites in ALS. Science. 373 (6551): 172-173.
NOSTER & Science Microbiome Grand Prize Essay.
2020
Ben Baruch B, Mantsur E, Franco-Barraza J, Blacher E, Cukierman E and Stein R. (2020). CD38 in cancer-associated fibroblasts promotes pro-tumoral activity. Laboratory Investigation. 100: 1517-1531.
2019
Blacher E*, Bashiardes S*, Rothschild D*, Shapiro H*, Mor U, Dori-Bachash M, Kleimeyer C, Moresi C, Harnik Y, Zur M, Zabari M, Ben-Zeev Brik R, Kviatcovsky D, Zmora N, Cohen Y, Bar N, Levi I, Amar N, Mehlman T, Brandis A, Biton I, Kuperman Y, Tsoory M, Alfahel L, Harmelin A, Schwartz M, Israelson A, Arike L, Johansson MEV, Hansson GC, Gotkine M, Segal E and Elinav E. (2019). Potential roles of gut microbiome and metabolites in modulating ALS in mice. Nature. 572: 474-480.
Featured in Bucci, M. A NAMe-tag for ALS. Nat Chem Biol 15, 933 (2019). https://doi.org/10.1038/s41589-019-0374-7 and in more than a hundred of general media publications and commentaries, including the BBC news, The Guardian and more.
2018
Thaiss CA, Levy M, Grosheva I, Zheng D, Soffer E, Blacher E, Braverman S, Tengeler AC, Barak O, Elazar M, Ben-Zeev R, Lehavi-Regev D, Katz MN, Pevsner-Fischer M, Gertler A, Halpern Z, Harmelin A, Amar S, Serradas P, Grosfeld A, Shapiro H, Geiger B and Elinav E. (2018). Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection. Science. 359: 1376-1383.
Featured in Science Zemp FJ et al, Many Fences Make Better Neighbors (2018), and in over 100 general media publications and commentaries.
Ben Baruch B*, Blacher E*, Shwartz H, Vaknine H, Erez N and Stein R. (2018). Stromal CD38 regulates progression of primary melanoma and generation of spontaneous metastasis. Oncotarget. 9: 31797-31811.
2017
Kundu P*, Blacher E*, Petresson S and Elinav E. (2017). Our gut microbiome: the evolving inner self. Cell. 171: 1481-1493.
Blacher E*, Levy M*, Tatirovsky E and Elinav E. (2017). Microbiome-modulated metabolites at the interface of host immunity. Journal of Immunology. 98: 572-580.
Levy M*, Blacher E*, Tatirovsky E and Elinav E. (2017). Microbiome, metabolites and host immunity. Current Opinion in Microbiology. 35: 8-15.
2016
Pevsner-Fischer M*, Blacher E*, Tatirovsky E, Ben-Dov IZ and Elinav E. (2016). The gut microbiome and hypertension. Current Opinion in Nephrology and Hypertension. 25: 1062-4821.
Schwartz H, Blacher E, Amer M, Livneh N, Abramovitz L, Klein A, Ben-Shushan D, Sofer S, Blazquez R, Barrantes-Freer A, Muller M, Muller-Decker K, Stein R, Tsarfaty G, Satchi-Fainaro R, Umansky V, Pukrop T and Erez N. (2016). Incipient melanoma brain metastases instigate astrogliosis and neuroinflammation. Cancer Research. 15: 4359-4371.
2015
Blacher E, Dadali T, Haupenthal V. J, Grimm MOW, Hartmann T, Lund FE, Stein R and Levy A. (2015). Alzheimer's disease pathology is attenuated in a CD38‐deficient mouse model. Annals of Neurology. 78: 88-103.
Blacher E, Ben Baruch B, Levy A, Geva N, Green KD, Garneau-Tsodikova S, Fridman M. and Stein R. (2015). Inhibition of glioma progression by a newly discovered CD38 inhibitor. International Journal of Cancer. 136: 1422-1433.
Blacher E, Levy A, Ben Baruch B, Green KD, Garneau-Tsodikova S, Fridman M. and Stein R. (2015). Targeting CD38 in the tumor microenvironment; a novel approach to treat glioma. Cancer Cell and Microenvironment. 2: 1-6.
Shaul P, Steinbuch K, Blacher E, Stein R and Fridman M. (2015). Exploring the effects of glycosylation and etherification of the side-chains of the anti-cancer drug mitoxantrone. ChemMedChem. 10: 1528-1538.
2013
Aizman E, Blacher E, Ben-Moshe O, Kogan T, Kloog Y and Mor A. (2013). Therapeutic effect of farnesylthiosalicylic acid on adjuvant-induced arthritis in rats through suppressed release of inflammatory cytokines. Clinical and Experimental Immunology.175: 458-467.
2012
Levy A, Blacher E, Vaknine H, Lund F. E, Stein R and Mayo L. (2012). CD38 deficiency in the tumor microenvironment attenuates glioma progression and modulates features of tumor-associated microglia/macrophages. Neuro-Oncology. 14: 1037-1049.
2010
Lindenboim L, Blacher E, Borner C and Stein R. (2010). Regulation of stress-induced nuclear proteins' redistribution: a new function of Bax and Bak uncoupled from Bcl-xL. Cell Death and Differentiation. 17: 346–359.
